1-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine → 3-Ethylaminomethyl-3-hydroxypyrrolidine

HRID 1681591Notes

Reaction equation

HRID 1681591 reaction equation
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:14][NH:15][CH2:16][CH3:17])([OH:13])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH2:16]([NH:15][CH2:14][C:10]1([OH:13])[CH2:11][CH2:12][NH:8][CH2:9]1)[CH3:17]

Participants

4

Reactant 1

HCID 145784521-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine

Product 1

HCID 145784503-Ethylaminomethyl-3-hydroxypyrrolidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

10 g (42.7 mmol) of 1-benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine in 60 ml of methanol are hydrogenated using 2 g of palladium/active carbon (10%) at 92° C. and 107 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.

Workup

  1. customat 92° C.
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-e4e021e5dca74120baeabfd04c0c1200
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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