HCID 19805343, compound → HCID 19382179, compound

HRID 1681593Notes

Reaction equation

HRID 1681593 reaction equation
[Cl-:1].[Cl-].C([N:10]1[CH2:14][CH2:13][C:12]([CH2:16][NH:17][CH:18]2[CH2:20][CH2:19]2)([OH:15])[CH2:11]1)C1C=CC=CC=1>CO.[Pd]>[ClH:1].[ClH:1].[CH:18]1([NH:17][CH2:16][C:12]2([OH:15])[CH2:13][CH2:14][NH:10][CH2:11]2)[CH2:20][CH2:19]1

Participants

4

Reactant 1

HCID 19805343HCID 19805343, compound

Product 1

HCID 19382179HCID 19382179, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

7.9 g (24.7 mmol) of 1-benzyl-3-cyclopropylaminomethyl-3-hydroxypyrrolidine dichloride in 100 ml of methanol are hydrogenated on 2 g of palladium/active carbon (10%) at 50° C. and 100 bar. The product is filtered off with suction and concentrated, and the residue is triturated with butanol. The crystalline salt is filtered off with suction, washed with acetone and dried.

Workup

  1. filtrationThe product is filtered off with suction
  2. concentrationconcentrated
  3. customthe residue is triturated with butanol
  4. filtrationThe crystalline salt is filtered off with suction
  5. washwashed with acetone
  6. customdried

Sources & evidence

ORD record
ord-18d5d41c44aa4b83b06cb7c6ab1a33fd
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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