HCID 14578461, compound → HCID 14578465, compound

HRID 1681595Notes

Reaction equation

HRID 1681595 reaction equation
[OH:1][C:2]1([CH2:12][NH:13][CH3:14])[CH2:7][CH2:6][CH2:5][N:4](C(OC)=O)[CH2:3]1>O>[OH:1][C:2]1([CH2:12][NH:13][CH3:14])[CH2:7][CH2:6][CH2:5][NH:4][CH2:3]1

Participants

3

Reactant 1

HCID 14578461HCID 14578461, compound

Product 1

HCID 14578465HCID 14578465, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8.7 g (43 mmol) of methyl 3-hydroxy-3-methylaminomethylpiperidine-1carboxylate are heated overnight under reflux with 24 g of Ba(OH)2. 8H2O in 240 ml of water. The product is filtered off from BaCO3 with suction and concentrated. The residue is boiled five times using 100 ml of dioxane each time, and the dioxane solution is concentrated and distilled.

Workup

  1. filtrationThe product is filtered off from BaCO3 with suction
  2. concentrationconcentrated
  3. concentrationthe dioxane solution is concentrated
  4. distillationdistilled

Sources & evidence

ORD record
ord-e4ee3a6334e2464cb295ac28ee766478
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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