HCID 14578462, compound → HCID 14578464, compound

HRID 1681597Notes

Reaction equation

HRID 1681597 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:10][CH2:9][CH2:8][N:7](C(OC)=O)[CH2:6]1)[CH3:2]>O>[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:10][CH2:9][CH2:8][NH:7][CH2:6]1)[CH3:2]

Participants

3

Reactant 1

HCID 14578462HCID 14578462, compound

Product 1

HCID 14578464HCID 14578464, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 g (46.2 mmol) of methyl 3-ethylaminomethyl-3-hydroxypiperidine-1-carboxylate are heated under reflux overnight with 28.5 g of Ba(OH)2. 8H2O in 280 ml of water. The product is filtered off from BaCO3 with suction and concentrated. The residue is boiled five times using 120 ml of dioxane each time, and the dioxane solution is concentrated and distilled.

Workup

  1. filtrationThe product is filtered off from BaCO3 with suction
  2. concentrationconcentrated
  3. concentrationthe dioxane solution is concentrated
  4. distillationdistilled

Sources & evidence

ORD record
ord-a2443374695c4f41b03d5ed524cac208
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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