Dimethylamine → 3-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol

HRID 1681606Notes

Reaction equation

HRID 1681606 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]2([O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][NH:16][CH3:17]>>[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]([CH2:11][N:16]([CH3:17])[CH3:15])([OH:12])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 111948055-Benzyl-1-oxa-5-azaspiro[2.4]heptane

Product 1

HCID 145784553-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol

Procedure

9.6 g (50 mmol) of 5-benzyl-5-aza-1-oxaspiro[2,4]heptane are added dropwise to 50 ml of dimethylamine solution (50%) and the mixture is stirred overnight at room temperature. The batch is then concentrated and the residue is distilled.

Workup

  1. concentrationThe batch is then concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-ecabe44131d34121aefb400b9f7803b4
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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