HCID 19382165, compound → 3-(Methoxymethyl)pyrrolidin-3-ol

HRID 1681609Notes

Reaction equation

HRID 1681609 reaction equation
C([N:8]1[CH2:12][CH2:11][C:10]([OH:16])([CH2:13][O:14][CH3:15])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[OH:16][C:10]1([CH2:13][O:14][CH3:15])[CH2:11][CH2:12][NH:8][CH2:9]1

Participants

4

Reactant 1

HCID 19382165HCID 19382165, compound

Product 1

HCID 219188513-(Methoxymethyl)pyrrolidin-3-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

10 g (45 mmol) of 1-benzyl-3-hydroxy-3-methoxymethylpyrrolidine are hydrogenated using 3 g of Pd/active carbon (10% Pd) in 200 ml of methanol at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Workup

  1. customat 100° C.
  2. filtrationThe catalyst is filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-79827a430ea14b218c702b3e207a0438
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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