反应详情

6.5 g Lithium aluminum hydride are suspended in 250 ml of dry diethylether. 42 g (0.16 mol) 1-benzyl-3-methoxypyrrolidine-3-carboxylic acid methylester are added dropwise. The mixture is stirred for 2 hours under reflux. Thereafter 6.5 ml of water, 6.5 ml 15% proof KOH and 6.5 ml of water are added, the inorganic salts are removed by filtration and washed twice with tetrahydrofuran. The organic solvents are removed from the filtrate in vacuo and the residue is distilled.

1. temperatureunder reflux
2. customthe inorganic salts are removed by filtration
3. washwashed twice with tetrahydrofuran
4. customThe organic solvents are removed from the filtrate in vacuo
5. distillationthe residue is distilled