1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 14578482, compound

HRID 1681619Notes

Reaction equation

HRID 1681619 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:16])=[C:11](F)[C:12]=3[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]2)[CH2:3][CH2:2]1.Cl.[CH:22]1([NH:25][CH2:26][C:27]2([OH:32])[CH2:31][CH2:30][NH:29][CH2:28]2)[CH2:24][CH2:23]1>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:16])=[C:11]([N:29]4[CH2:30][CH2:31][C:27]([CH2:26][NH:25][CH:22]5[CH2:23][CH2:24]5)([OH:32])[CH2:28]4)[C:12]=3[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 5354141-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 19805339HCID 19805339, compound

Product 1

HCID 14578482HCID 14578482, compound

Procedure

1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is reacted analogously to Example 6 with 3-cyclopropylaminomethyl-3-hydroxypyrrolidine hydrochloride to give 1-cyclopropyl-7-(3-cyclopropylaminomethyl-3 -hydroxy-1-pyrrolidinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of melting point 161°-162° (with decomposition).

Sources & evidence

ORD record
ord-c5cf86077e84492dbab14b665173b249
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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