Acetic Anhydride → HCID 10422961, compound

HRID 1681621Notes

Reaction equation

C(OC(NCC1(O)CCN([C:15]2[C:24]([F:25])=[C:23]3[C:18]([C:19](=[O:32])[C:20]([C:29]([OH:31])=[O:30])=[CH:21][N:22]3[CH:26]3[CH2:28][CH2:27]3)=[CH:17][C:16]=2[F:33])C1)=O)(C)(C)C.C(OC(=O)C)(=O)C>>[CH:26]1([N:22]2[C:23]3[C:18](=[CH:17][C:16]([F:33])=[CH:15][C:24]=3[F:25])[C:19](=[O:32])[C:20]([C:29]([OH:31])=[O:30])=[CH:21]2)[CH2:27][CH2:28]1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 19382235HCID 19382235, compound

Product 1

HCID 10422961HCID 10422961, compound

Procedure

Analogously to example 30 7-(3-tert.-butoxycarbonylaminomethyl-3-hydroxy-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-4-oxo-3-quinolinecarboxylic acid are reacted with acetic acid anhydride, yielding 7-3-acetoxy-3-tert.-butoxycarbonylaminomethyl-3-hydroxy-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, melting point: 215° C. (decomposition).

Sources & evidence

ORD record: ord-69d2f20cc9d94dd591b55f0240b08b5b
Source dataset: uspto-grants-1992_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05173484

Reaction notes

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