Ethanol → HCID 53730872, compound

Participants

Reaction Steps

Using a similar procedure to that described in Examples 2-16, but starting from 2-nitro-N-(prop-2-ynyl)benzamide (itself prepared from 2-nitrobenzoyl chloride and prop-2-ynylamine using the process described for the preparation of the starting material for Ex. 24), using a mixture of ethanol and water (95/5 v/v) in place of aqueous methanol as the reaction solvent and having a reaction duration of 3 hours, there was obtained 1,2-dihydro-2-allenyl-3H-indazol-3-one (Ex. 177) as a solid, m.p. 126-130° C. in 12% yield.

Provenance & Evidence