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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1681818Generated: October 26, 2026

11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → 11-[[2-[2-[2-(Diethylamino)ethoxy]ethyl]-1-piperidinyl]-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

https://huagongshe.com/reaction/1681818

Reaction equation

Participants

RoleNameHCIDCharge
Reactant11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 120053—
Reactant2-[2-[2-(Diethylamino)ethoxy]ethyl]piperidineHCID 15057321—
Product11-[[2-[2-[2-(Diethylamino)ethoxy]ethyl]-1-piperidinyl]-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 1980422144%

Reaction Steps

Prepared analogously to Example 1 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6- one and 2-[2-[2-(diethylamino)ethoxy]ethyl]piperidine (Bp.0.4 mmHg 95°-99° C.) in a yield of 44% of theory.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05175158
Source datasetuspto-grants-1992_12
ORD IDord-c35177d40b894570872a5fe9d9760418
Source noteuspto-grants-1992_12