HCID 14328501, compound → HCID 14700186, compound

HRID 1681849Notes

Reaction equation

HRID 1681849 reaction equation
[CH3:1][C:2]([CH3:14])([CH3:13])[C:3]([OH:12])([CH2:6][N:7]1[CH:11]=[N:10][CH:9]=[N:8]1)[C:4]#[CH:5].[Cl:15][O-].[Na+]>C(Cl)Cl>[Cl:15][C:5]#[C:4][C:3]([OH:12])([CH2:6][N:7]1[CH:11]=[N:10][CH:9]=[N:8]1)[C:2]([CH3:14])([CH3:13])[CH3:1]

Participants

4

Reactant 2

HCID 14328501HCID 14328501, compoundHCID 23665760Sodium Hypochlorite

Product 1

HCID 14700186HCID 14700186, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

9.65 (50 mmol) of 4,4-dimethyl-3-hydroxy-3-[(1,2,4-triazol-1-yl)-methyl]-1-pentine in 20 ml of methylene chloride are stirred for 3 days with 400 ml (150 mmol) of a solution of sodium hypochlorite at room temperature. The reaction mixture is then extracted by shaking with methylene chloride. After drying the organic phase and stripping off the solvent in vacuo, there are obtained 9.8 g (43 mmol; 86% of theory) of 1-chloro-4,4-dimethyl-3-hydroxy-3-[(1,2,4-triazol-1-yl)-methyl]-1-pentine having a melting point of 88° C.

Workup

  1. extractionThe reaction mixture is then extracted
  2. customAfter drying the organic phase

Sources & evidence

ORD record
ord-ffb5ac4270b14a499132d74d236ecf33
Source dataset
uspto-grants-1992_12
Patent number
US05175169

Reaction notes

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