HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Fluoroacetophenone → HCID 19804347, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Fluoroacetophenone | HCID 9828 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N,N-diethylpiperidin-4-amine | HCID 2758239 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Solvent | Dimethylformamide n-propanol | HCID 86598119 | — |
| Product | HCID 19804347 | HCID 19804347 | 52.3% |
Reaction Steps
2.1 g (13.25 mmol) of 4-(N,N-diethylamino)piperidine, 1.8 g (13.25 mmol) of 4-fluoroacetophenone and 7.3 g of potassium carbonate in 100 ml of dimethylformamide/n-propanol (1:1) were refluxed for 20 h. 1.9 g of 1-(4-acetylphenyl)-4-(N,N-diethylamino)piperidine were obtained as crystalline fumarate. Melting point 125°-127° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05175174 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-42ea07ddf0c0414bbb68812360a1c06a |
| Source note | uspto-grants-1992_12 |