Methyl iodide → 1-Methyl-3-triphenylmethyl-5(3-methyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidinium Iodide

HRID 1681896Notes

Reaction equation

HRID 1681896 reaction equation
[CH3:1][I:2].[C:3]1([C:9]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:10]2[CH2:15][CH:14]([C:16]3[O:20][N:19]=[C:18]([CH3:21])[N:17]=3)[CH2:13][N:12]=[CH:11]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(Cl)(Cl)Cl>[I-:2].[CH3:1][NH+:12]1[CH2:13][CH:14]([C:16]2[O:20][N:19]=[C:18]([CH3:21])[N:17]=2)[CH2:15][N:10]([C:9]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:11]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 100244281-Triphenylmethyl-1,4,5,6-tetrahydro-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidine

Product 1

HCID 703426091-Methyl-3-triphenylmethyl-5(3-methyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidinium IodideYield 100%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Methyliodide (38 μl, 0.6 mmol) was added to a stirred solution of 1-triphenylmethyl-5(3-methyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine (250 mg, 0.6 mmol) in chloroform (lml), in a round bottom flask with a septum, at room temperature. After 12 hours stirring the solvents were evaporated in vacuo giving 330 mg (100%) crude white crystals identified by 300 MHz nmr.

Workup

  1. customwere evaporated in vacuo

Sources & evidence

ORD record
ord-2c98cb46c1b64de9b28445cee63bbac9
Source dataset
uspto-grants-1992_12
Patent number
US05175166

Reaction notes

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