HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Amino-2-(pyrimidin-5-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | alpha-Amino-5-pyrimidineacetonitrile | HCID 20080448 | — |
| Product | 2-Amino-2-(pyrimidin-5-yl)acetamide | HCID 20080413 | 81% |
Reaction Steps
Amino(pyrimidin-5-yl)acetonitrile (1.1 g, 8.2 mmol) is hydrolyzed by refluxing in a small volume of dilute HCl for 1 hour. The pH is raised to 10 by addition of saturated sodium carbonate and the mixture then extracted with chloroform. Evaporation of the chloroform and chromatography (silica, chloroform/methanol) gives product as a yellow solid 950 mg (81%) ms m/z=142.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05175166 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-9d404f5546614c35a0c8b8e4181c91fd |
| Source note | uspto-grants-1992_12 |