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Trityl chloride → Amino(1-triphenylmethyl-1,4,5,6-tetrahydropyrimidin-5-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trityl chloride | HCID 6456 | — |
| 反応物 | Amino(1,4,5,6-tetrahydropyrimidine-5-yl)acetamide dihydrochloride | HCID 20080419 | — |
| 反応物 | 3-(Cycloundecen-1-yl)-1,2-diazacycloundec-2-ene | HCID 53630274 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Amino(1-triphenylmethyl-1,4,5,6-tetrahydropyrimidin-5-yl)acetamide | HCID 20080439 | 71% |
反応手順
Amino(1,4,5,6-tetrahydropyrimidine-5-yl)acetamide dihydrochloride (1.33 g, 5.8 mmol), diazabicycloundecene (DBU, 2.6 ml, 17.4 mmol), and tritylchloride (1.61 g, 5.8 mmol) are dissolved in anhydrous DMF (20 ml) with stirring under nitrogen at room temperature. After 18 hours stirring the suspension is evaporated in vacuo, and the residue chromatographed (silica, chloroform/methanol, 9:1) to yield 1.64 g (71%) white crystalline solid, identified by 300 MHz nmr and ms m/z=398.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05175166 |
| 出典データセット | uspto-grants-1992_12 |
| ORD ID | ord-1521d6b8182b4267b523d3cb220fc94c |
| 出典メモ | uspto-grants-1992_12 |