HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butanal, oxime → HCID 5273047, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butanal, oxime | HCID 8069 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | Propionaldehyde oxime | HCID 641641 | — |
| Reactant | HCID 5273046 | HCID 5273046 | — |
| Reactant | 1,2,4-Oxadiazole | HCID 6451463 | — |
| Catalyst | Pyridine | HCID 1049 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 5273047 | HCID 5273047 | 58% |
Reaction Steps
Following a procedure similar to that of Example 8(c) but substituting 2.6 g butyraldehyde oxime for the propionaldehyde oxime and using 3.99 g N-chlorosuccinimide, 2 drops pyridine, 50 ml N-methylpyrrolidinone, 2.7 g of the 1,2,4-oxadiazole of part (b) of Example 8 and 4.2 ml triethylamine, there was obtained after chromatography (MPLC, silica gel, 30:70 ethyl acetate/hexane) 2.06 g (58%) of the title compound as white needles, m.p. 69.0°-70.0° C. when recrystallized from methyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05175178 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-a9a521966d824293ad2194425002140a |
| Source note | uspto-grants-1992_12 |