Methyl chloroacetate → HCID 13336496, compound

HRID 1681947Notes

Reaction equation

HRID 1681947 reaction equation
ClCC(OC)=O.[CH2:7]([C:9]1[O:10][C:11]2[CH:31]=[CH:30][CH:29]=[CH:28][C:12]=2[C:13]=1[C:14]([C:16]1[CH:27]=[CH:26][C:19]([O:20][CH2:21][C:22](OC)=[O:23])=[CH:18][CH:17]=1)=[O:15])[CH3:8].O.[NH3:33]>>[CH2:7]([C:9]1[O:10][C:11]2[CH:31]=[CH:30][CH:29]=[CH:28][C:12]=2[C:13]=1[C:14]([C:16]1[CH:27]=[CH:26][C:19]([O:20][CH2:21][C:22]([NH2:33])=[O:23])=[CH:18][CH:17]=1)=[O:15])[CH3:8]

Participants

4

Reactant 3

HCID 7295Methyl chloroacetateHCID 12896473Azane;hydrateHCID 13336500HCID 13336500, compound2×

Product 1

HCID 13336496HCID 13336496, compound

Procedure

According to the Procedure B of Example 1, the intermediate of the Example 3 was reacted with methyl chloroacetate. The resulting product methyl 4-(2-ethyl-benzofuroyl) phenoxyacetate (Compound 11) was treated with concentrated ammonia water 28%) 100 ml and was stirred under ice-cooled condition for three hours. The white powder thus obtained, after drying was recrystallized from methanol.

Workup

  1. temperaturecooled condition for three hours
  2. customThe white powder thus obtained
  3. customafter drying
  4. customwas recrystallized from methanol

Sources & evidence

ORD record
ord-1f297ad711984f97a0e28360627ff1a0
Source dataset
uspto-grants-1992_12
Patent number
US05175184

Reaction notes

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