HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(hexahydro-azepin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → 3-[(N-(3-(4-Amino-3,5-dibromo-phenoxy)-propyl)-hexahydro-azepin-3-yl)-methyl]-7, 8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one-dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(hexahydro-azepin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one | HCID 19803737 | — |
| Reactant | 3-(4-Amino-3,5dibromo-phenoxy)-propyl chloride | HCID 19804061 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-[(N-(3-(4-Amino-3,5-dibromo-phenoxy)-propyl)-hexahydro-azepin-3-yl)-methyl]-7, 8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one-dihydrochloride | HCID 67918207 | — |
Reaction Steps
Prepared from 1.2 g (3.6 mmol) of 3-[(hexahydro-azepin-3-yl)methyl]-7,8-dimethoxy-1,3,4, 5-tetrahydro-2H-3-benzazepin-2-one and 1.36 g (3.96 mmol) of 3-(4-amino-3,5-dibromo-phenoxy)-propyl chloride in 5 ml triethylamine analogously to Example 26.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05175157 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-935386be48c748fc866a409f1adcdce6 |
| Source note | uspto-grants-1992_12 |