1-(3-Chloropropoxy)-3-methylbenzene → 3-[(N-(3-(3-Methyl-phenoxy)-propyl)-piperidin-3-yl)-methyl]-7,8-methylendioxy-1,3,4, 5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride

HRID 1682015Notes

Reaction equation

HRID 1682015 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[C:14](=[O:15])[CH2:13][C:12]3[CH:16]=[C:17]4[O:22][CH2:21][O:20][C:18]4=[CH:19][C:11]=3[CH2:10][CH2:9]2)[CH2:2]1.[CH3:23][C:24]1[CH:25]=[C:26]([CH:32]=[CH:33][CH:34]=1)[O:27][CH2:28][CH2:29][CH2:30][Cl:31]>>[ClH:31].[CH3:23][C:24]1[CH:25]=[C:26]([CH:32]=[CH:33][CH:34]=1)[O:27][CH2:28][CH2:29][CH2:30][N:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[C:14](=[O:15])[CH2:13][C:12]3[CH:16]=[C:17]4[O:22][CH2:21][O:20][C:18]4=[CH:19][C:11]=3[CH2:10][CH2:9]2)[CH2:2]1

Participants

3

Reactant 2

HCID 127603061-(3-Chloropropoxy)-3-methylbenzeneHCID 543405853-[(piperidin-3-yl)-methyl]-7,8-methylenedioxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Product 1

HCID 679184693-[(N-(3-(3-Methyl-phenoxy)-propyl)-piperidin-3-yl)-methyl]-7,8-methylendioxy-1,3,4, 5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride

Procedure

Prepared from 3-[(piperidin-3-yl)-methyl]-7,8-methylenedioxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one and 3-(3-methylphenoxy)-propylchloride analogously to Example 1.

Sources & evidence

ORD record
ord-8ef8a59f68ae40c29391a362e0225b9c
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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