2-(4-Amino-3,5-dichloro-phenyl)-ethylbromide → 3-[(N-(2-(4-Amino-3,5-dichloro-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4, 5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride

HRID 1682016Notes

Reaction equation

HRID 1682016 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[C:14](=[O:15])[CH2:13][C:12]3[CH:16]=[C:17]([O:22][CH3:23])[C:18]([O:20][CH3:21])=[CH:19][C:11]=3[CH2:10][CH2:9]2)[CH2:2]1.[NH2:24][C:25]1[C:30]([Cl:31])=[CH:29][C:28]([CH2:32][CH2:33]Br)=[CH:27][C:26]=1[Cl:35]>>[ClH:31].[NH2:24][C:25]1[C:26]([Cl:35])=[CH:27][C:28]([CH2:32][CH2:33][N:1]2[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]3[C:14](=[O:15])[CH2:13][C:12]4[CH:16]=[C:17]([O:22][CH3:23])[C:18]([O:20][CH3:21])=[CH:19][C:11]=4[CH2:10][CH2:9]3)[CH2:2]2)=[CH:29][C:30]=1[Cl:31]

Participants

3

Reactant 2

HCID 198035132-(4-Amino-3,5-dichloro-phenyl)-ethylbromideHCID 198038413-[(piperidin-3-yl)-methyl]-7,8-dimethoxy1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Product 1

HCID 679183733-[(N-(2-(4-Amino-3,5-dichloro-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4, 5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride

Procedure

Prepared from 3-[(piperidin-3-yl)-methyl]-7,8-dimethoxy1,3,4,5-tetrahydro-2H-3-benzazepin-2-one and 2-(4-amino-3,5-dichloro-phenyl)-ethylbromide analogously to Example 1.

Sources & evidence

ORD record
ord-72f1e459e0a54dcfb98416d931ae90a3
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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