HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Chloroethyl)phenyl methyl ether → 3-[(N-(2-(4-Methoxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-methylenedioxy-1,3,4, 5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Chloroethyl)phenyl methyl ether | HCID 87513 | — |
| Reactant | 3-[(piperidin-3-yl)-methyl]-7,8-methylenedioxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one | HCID 54340585 | — |
| Solvent | Dimethylformamide potassium carbonate | HCID 86662288 | — |
| Product | 3-[(N-(2-(4-Methoxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-methylenedioxy-1,3,4, 5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride | HCID 67917868 | — |
Reaction Steps
Prepared from 3-[(piperidin-3-yl)-methyl]-7,8-methylenedioxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one and 2-(4-methoxyphenyl)-ethylchloride in dimethyl-formamide/potassium carbonate at 120° C. analogously to Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05175157 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-85ae93edf75246178b30457515b835c0 |
| Source note | uspto-grants-1992_12 |