Methanesulfonyl chloride → HCID 19803977, compound

HRID 1682018Notes

Reaction equation

Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH2:16][CH:15]([CH2:19][N:20]3[C:26](=[O:27])[CH2:25][C:24]4[CH:28]=[C:29]([O:34][CH3:35])[C:30]([O:32][CH3:33])=[CH:31][C:23]=4[CH2:22][CH2:21]3)[CH2:14]2)[CH:7]=[CH:8][C:9]=1[OH:10].[CH3:36][S:37]([Cl:40])(=[O:39])=[O:38]>>[ClH:40].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH2:16][CH:15]([CH2:19][N:20]3[C:26](=[O:27])[CH2:25][C:24]4[CH:28]=[C:29]([O:34][CH3:35])[C:30]([O:32][CH3:33])=[CH:31][C:23]=4[CH2:22][CH2:21]3)[CH2:14]2)[CH:7]=[CH:8][C:9]=1[O:10][S:37]([CH3:36])(=[O:39])=[O:38]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 19804150HCID 19804150, compound

Product 1

HCID 19803977HCID 19803977, compound

Procedure

Prepared from 3-[(N-(2-(3-methoxy-4-hydroxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride and methanesulphonic acid chloride analogously to Example 9.

Sources & evidence

ORD record: ord-25207273d30a4a74acd79980a2c3e8e6
Source dataset: uspto-grants-1992_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05175157

Reaction notes

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