2-(4-Benzyloxy-3-methoxy-phenyl)-ethylbromide → 3-[(N-(2-(4-Benzyloxy-3-methoxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

HRID 1682019Notes

Reaction equation

HRID 1682019 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[C:14](=[O:15])[CH2:13][C:12]3[CH:16]=[C:17]([O:22][CH3:23])[C:18]([O:20][CH3:21])=[CH:19][C:11]=3[CH2:10][CH2:9]2)[CH2:2]1.[CH2:24]([O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][CH2:39]Br)=[CH:34][C:33]=1[O:41][CH3:42])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:24]([O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][CH2:39][N:1]2[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]3[C:14](=[O:15])[CH2:13][C:12]4[CH:16]=[C:17]([O:22][CH3:23])[C:18]([O:20][CH3:21])=[CH:19][C:11]=4[CH2:10][CH2:9]3)[CH2:2]2)=[CH:34][C:33]=1[O:41][CH3:42])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 138915532-(4-Benzyloxy-3-methoxy-phenyl)-ethylbromideHCID 198038413-[(piperidin-3-yl)-methyl]-7,8-dimethoxy1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Product 1

HCID 198035793-[(N-(2-(4-Benzyloxy-3-methoxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Procedure

Prepared from 3-[(piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one and 2-(4-benzyloxy-3-methoxy-phenyl)-ethylbromide analogously to Example 1.

Sources & evidence

ORD record
ord-b588677a78134b04a3940d9a9dae706a
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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