3-[(N-(2-(4-Benzyloxy-3-methoxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → 3-[(N-(2-(3-Methoxy-4-hydroxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

HRID 1682020Notes

Reaction equation

HRID 1682020 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][CH2:20][CH:19]([CH2:23][N:24]3[C:30](=[O:31])[CH2:29][C:28]4[CH:32]=[C:33]([O:38][CH3:39])[C:34]([O:36][CH3:37])=[CH:35][C:27]=4[CH2:26][CH2:25]3)[CH2:18]2)=[CH:11][C:10]=1[O:40][CH3:41])C1C=CC=CC=1>C(O)(=O)C>[CH3:41][O:40][C:10]1[CH:11]=[C:12]([CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][CH2:20][CH:19]([CH2:23][N:24]3[C:30](=[O:31])[CH2:29][C:28]4[CH:32]=[C:33]([O:38][CH3:39])[C:34]([O:36][CH3:37])=[CH:35][C:27]=4[CH2:26][CH2:25]3)[CH2:18]2)[CH:13]=[CH:14][C:9]=1[OH:8]

Participants

3

Reactant 1

HCID 198035793-[(N-(2-(4-Benzyloxy-3-methoxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Product 1

HCID 198040003-[(N-(2-(3-Methoxy-4-hydroxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Prepared from 3-[(N-(2-(4-benzyloxy-3-methoxy-phenyl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-I,3,4,5-tetrahydro-2H-3-benzazepin-2-one in glacial acetic acid analogously to Example 8.

Sources & evidence

ORD record
ord-4f564158067d4e2088483d29c2dd07a7
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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