Potassium Carbonate → HCID 19803538, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.3 g (0.0034 mol) of 2-[(N-(3-chloropropyl)-piperidine-3-yl)-methyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline, 15 ml of dimethylsulphoxide, 1.4 g (0.1 mol) of potassium carbonate and 1 g (0.0066 mol) of 3,4-dimethyl-N-ethylaniline is heated to 120° C. for 6 hours. The reaction mixture is poured onto ice water, extracted with ethyl acetate, the organic phase is washed with water, dried over sodium sulphate and evaporated down in vacuo. The residue obtained is purified over silica gel (0.036-0.2 mm) with 5% ethanol in methylene chloride.

Provenance & Evidence