2-(2-Bromoethyl)naphthalene → 2-[(N-(2-(Naphth-2-yl)-ethyl)-hexahydro-azepin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrobromide

HRID 1682027Notes

Reaction equation

HRID 1682027 reaction equation
[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]([CH2:8][N:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][C:13]4[O:21][CH2:20][O:19][C:14]=4[CH:15]=3)[C:10]2=[O:22])[CH2:2]1.[Br:23][CH2:24][CH2:25][C:26]1[CH:35]=[CH:34][C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=1>>[BrH:23].[CH:27]1[C:28]2[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:34]=[CH:35][C:26]=1[CH2:25][CH2:24][N:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]([CH2:8][N:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][C:13]4[O:21][CH2:20][O:19][C:14]=4[CH:15]=3)[C:10]2=[O:22])[CH2:2]1

Participants

3

Reactant 2

HCID 2282702-(2-Bromoethyl)naphthaleneHCID 143068422-[(Hexahydro-azepin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline

Product 1

HCID 198037292-[(N-(2-(Naphth-2-yl)-ethyl)-hexahydro-azepin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrobromide

Procedure

Prepared from 2-[(hexahydro-azepin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline and 2-(2-bromo-ethyl)-naphthalene analogously to Example 1.

Sources & evidence

ORD record
ord-039e4d3bc6a34a7483e70ee41fc7c5ba
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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