2-[3-(Piperidin-3-yl)-propyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline → 2-[3-(N-(3-(3,4-Methylenedioxy-phenoxy)-propyl)-piperidin-3-yl)-propyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

HRID 1682029Notes

Reaction equation

HRID 1682029 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][CH2:8][CH2:9][N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][C:14]([O:22][CH3:23])=[C:15]([O:20][CH3:21])[CH:16]=3)[C:11]2=[O:24])[CH2:2]1.[Cl:25][CH2:26][CH2:27][CH2:28][O:29][C:30]1[CH:35]=[CH:34][C:33]2[O:36][CH2:37][O:38][C:32]=2[CH:31]=1>>[ClH:25].[CH2:37]1[O:36][C:33]2[CH:34]=[CH:35][C:30]([O:29][CH2:28][CH2:27][CH2:26][N:1]3[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][CH2:8][CH2:9][N:10]4[CH2:19][CH2:18][C:17]5[C:12](=[CH:13][C:14]([O:22][CH3:23])=[C:15]([O:20][CH3:21])[CH:16]=5)[C:11]4=[O:24])[CH2:2]3)=[CH:31][C:32]=2[O:38]1

Participants

3

Reactant 2

HCID 198036352-[3-(Piperidin-3-yl)-propyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinolineHCID 198038641-Chloro-3-(3,4-methylenedioxy-phenoxy)-propane

Product 1

HCID 198041872-[3-(N-(3-(3,4-Methylenedioxy-phenoxy)-propyl)-piperidin-3-yl)-propyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

Procedure

Prepared from 2-[3-(piperidin-3-yl)-propyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline and 1-chloro-3-(3,4-methylenedioxy-phenoxy)-propane analogously to Example 1.

Sources & evidence

ORD record
ord-f52ea41bf40e4c149b935a8ceb32bf28
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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