2-[2-(Piperid-2-yl)-ethyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline → 2-[2-(N-(3-(3,4-Methylenedioxy-phenoxy)-propyl)-piperid-2-yl)-ethyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

HRID 1682033Notes

Reaction equation

HRID 1682033 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[CH:15]=2)[C:10]1=[O:23].[Cl:24][CH2:25][CH2:26][CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]2[O:35][CH2:36][O:37][C:31]=2[CH:30]=1>>[ClH:24].[CH2:36]1[O:35][C:32]2[CH:33]=[CH:34][C:29]([O:28][CH2:27][CH2:26][CH2:25][N:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]3[CH2:7][CH2:8][N:9]3[CH2:18][CH2:17][C:16]4[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[CH:15]=4)[C:10]3=[O:23])=[CH:30][C:31]=2[O:37]1

Participants

3

Reactant 2

HCID 198037012-[2-(Piperid-2-yl)-ethyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinolineHCID 198038641-Chloro-3-(3,4-methylenedioxy-phenoxy)-propane

Product 1

HCID 198041322-[2-(N-(3-(3,4-Methylenedioxy-phenoxy)-propyl)-piperid-2-yl)-ethyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

Procedure

Prepared from 2-[2-(piperid-2-yl)-ethyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline and 1-chloro-3-(3,4-methylenedioxy-phenoxy)-propane analogously to Example 1.

Sources & evidence

ORD record
ord-b96018171ccc475ab5cb679fdf309679
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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