2,4-Dichloro-1-(4-chlorobutoxy)benzene → 2-[(N-(4-(2,4-Dichloro-phenoxy)-butyl)-piperidin-3-yl)-methyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

HRID 1682036Notes

Reaction equation

HRID 1682036 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([O:20][CH3:21])=[C:13]([O:18][CH3:19])[CH:14]=3)[C:9]2=[O:22])[CH2:2]1.[Cl:23][CH2:24][CH2:25][CH2:26][CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][C:30]=1[Cl:36]>>[ClH:23].[Cl:36][C:30]1[CH:31]=[C:32]([Cl:35])[CH:33]=[CH:34][C:29]=1[O:28][CH2:27][CH2:26][CH2:25][CH2:24][N:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([O:20][CH3:21])=[C:13]([O:18][CH3:19])[CH:14]=3)[C:9]2=[O:22])[CH2:2]1

Participants

3

Reactant 2

HCID 129286352,4-Dichloro-1-(4-chlorobutoxy)benzeneHCID 14306655HCID 14306655, compound

Product 1

HCID 198035542-[(N-(4-(2,4-Dichloro-phenoxy)-butyl)-piperidin-3-yl)-methyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

Procedure

Prepared from 2-[(piperidin-3-yl)-methyl]-6,7-dimethyoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline and 1-chloro-4-(2,4-dichlorophenoxy)-butane analogously to Example 1.

Sources & evidence

ORD record
ord-971b011bddd643b09bc5ecb58f72f334
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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