1-(3-Chloropropoxy)-4-methoxybenzene → 2-[(N-(3-(4-Methoxy-phenoxy)-propyl)-piperidin-3-yl)-methyl]-6,7-dimethyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

HRID 1682039Notes

Reaction equation

HRID 1682039 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([CH3:19])=[C:13]([CH3:18])[CH:14]=3)[C:9]2=[O:20])[CH2:2]1.[Cl:21][CH2:22][CH2:23][CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=1>>[ClH:21].[CH3:33][O:32][C:29]1[CH:30]=[CH:31][C:26]([O:25][CH2:24][CH2:23][CH2:22][N:1]2[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]3[CH2:17][CH2:16][C:15]4[C:10](=[CH:11][C:12]([CH3:19])=[C:13]([CH3:18])[CH:14]=4)[C:9]3=[O:20])[CH2:2]2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 126856121-(3-Chloropropoxy)-4-methoxybenzeneHCID 198037552-[(Piperidin-3-yl)-methyl]-6,7-dimethyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline

Product 1

HCID 198035092-[(N-(3-(4-Methoxy-phenoxy)-propyl)-piperidin-3-yl)-methyl]-6,7-dimethyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

Procedure

Prepared from 2-[(piperidin-3-yl)-methyl]-6,7-dimethyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline and 1-chloro-3-(4-methoxy-phenoxy)-propane analogously to Example 1.

Sources & evidence

ORD record
ord-27838536b498405193e5746a84994158
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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