3-(3-Methoxyphenoxy)-propyl chloride → 2-[(N-(3-(3-Methoxy-phenoxy)-propyl)-piperidin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

HRID 1682040Notes

Reaction equation

HRID 1682040 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]4[O:20][CH2:19][O:18][C:13]=4[CH:14]=3)[C:9]2=[O:21])[CH2:2]1.[Cl:22][CH2:23][CH2:24][CH2:25][O:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH3:34])[CH:28]=1>>[ClH:22].[CH3:34][O:33][C:29]1[CH:28]=[C:27]([CH:32]=[CH:31][CH:30]=1)[O:26][CH2:25][CH2:24][CH2:23][N:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]4[O:20][CH2:19][O:18][C:13]=4[CH:14]=3)[C:9]2=[O:21])[CH2:2]1

Participants

3

Reactant 2

HCID 167929103-(3-Methoxyphenoxy)-propyl chlorideHCID 198037112-[(Piperidin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline

Product 1

HCID 198035362-[(N-(3-(3-Methoxy-phenoxy)-propyl)-piperidin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

Procedure

Prepared from 2-[(piperidin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline and 1-chloro-3-(3-methoxy-phenoxy)-propane analogously to Example 1.

Sources & evidence

ORD record
ord-f95aeaf8cb884937858bfd8adc3b9620
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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