Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1682048Generated: October 27, 2026

Corydaldine → 2-[(N-(1-(Pyrid-4-yl)-methyl)-piperidin-3-yl)-methyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-dihydrochloride-monohydrate

https://huagongshe.com/reaction/1682048

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCorydaldineHCID 610097—
ReactantHCID 19803951HCID 19803951—
ReactantPotassium tert-butoxideHCID 23665647—
SolventDimethyl SulfoxideHCID 679—
Product2-[(N-(1-(Pyrid-4-yl)-methyl)-piperidin-3-yl)-methyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-dihydrochloride-monohydrateHCID 19803955—

Reaction Steps

Prepared from 6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline in dimethylsulphoxide with potassium tert.butoxide and 3-chloromethyl-N-[1-(pyrid-4-yl)-methyl]-piperidine analogously to Example 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05175157
Source datasetuspto-grants-1992_12
ORD IDord-a3485fdb76cd443ab015071c4f15c15c
Source noteuspto-grants-1992_12