1368908-77-3 → HCID 19803787, compound

HRID 1682051Notes

Reaction equation

HRID 1682051 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[C:8](=[O:13])[NH:7][CH2:6][CH2:5]2.CC(C)([O-:17])C.[K+].[Cl:20][CH2:21][CH:22]1[CH2:27][CH2:26][CH2:25][N:24]([CH2:28][CH2:29][CH2:30][C:31]2[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=2)[CH2:23]1>CS(C)=O>[OH2:13].[OH2:17].[ClH:20].[ClH:20].[N:33]1[CH:34]=[CH:35][CH:36]=[C:31]([CH2:30][CH2:29][CH2:28][N:24]2[CH2:25][CH2:26][CH2:27][CH:22]([CH2:21][N:7]3[CH2:6][CH2:5][C:4]4[C:9](=[CH:10][C:11]([CH3:12])=[C:2]([CH3:1])[CH:3]=4)[C:8]3=[O:13])[CH2:23]2)[CH:32]=1

Participants

5

Reactant 3

HCID 178048941368908-77-3HCID 19803735HCID 19803735, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 19803787HCID 19803787, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Prepared from 6,7-dimethyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline in dimethylsulphoxide with potassium tert.butoxide and 3-chloromethyl-N-[3-(pyrid-3-yl)-propyl]-piperidine analogously to Example 2.

Sources & evidence

ORD record
ord-6b2011bd50e541e3b5c8f4f479f74442
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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