Noroxyhydrastinine → 2-[(N-(3-(Pyrid-3-yl)-propyl)-pyrrolidin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-dihydrochloride

HRID 1682052Notes

Reaction equation

HRID 1682052 reaction equation
[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][NH:8][C:9]3=[O:14])=[CH:4][C:3]=2[O:2]1.[Cl:15][CH2:16][CH:17]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[CH2:18]1>>[ClH:15].[ClH:15].[N:27]1[CH:28]=[CH:29][CH:30]=[C:25]([CH2:24][CH2:23][CH2:22][N:19]2[CH2:20][CH2:21][CH:17]([CH2:16][N:8]3[CH2:7][CH2:6][C:5]4[C:10](=[CH:11][C:12]5[O:13][CH2:1][O:2][C:3]=5[CH:4]=4)[C:9]3=[O:14])[CH2:18]2)[CH:26]=1

Participants

3

Reactant 2

HCID 89047NoroxyhydrastinineHCID 198034883-chloromethyl-N-[3-(pyrid-3-yl)-propyl]-pyrrolidine

Product 1

HCID 198035912-[(N-(3-(Pyrid-3-yl)-propyl)-pyrrolidin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-dihydrochloride

Procedure

Prepared from 6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline and 3-chloromethyl-N-[3-(pyrid-3-yl)-propyl]-pyrrolidine analogously to Example 2.

Sources & evidence

ORD record
ord-758f3dee1fbb4adf88020d3749134a9a
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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