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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1682055Generated: November 3, 2026

7,8-methylenedioxy-2-oxo-1,3-dihydro-2H-3-benzazepine → 3-[2-(N-(3-(Pyrid-4-yl)-propyl)-piperid-2-yl)-ethyl]-7,8-methylenedioxy-2-oxo-1,3-dihydro-2H-3-benzazepine-dihydrochloride-dihydrate

https://huagongshe.com/reaction/1682055

Reaction equation

Participants

RoleNameHCIDCharge
Reactant7,8-methylenedioxy-2-oxo-1,3-dihydro-2H-3-benzazepineHCID 13092502—
Reactant2-(2-chloroethyl)-N-[3-(pyrid-4-yl)-propyl]piperidineHCID 19803633—
SolventDimethyl SulfoxideHCID 679—
SolventPotassium tert-butoxideHCID 23665647—
Product3-[2-(N-(3-(Pyrid-4-yl)-propyl)-piperid-2-yl)-ethyl]-7,8-methylenedioxy-2-oxo-1,3-dihydro-2H-3-benzazepine-dihydrochloride-dihydrateHCID 67917974—

Reaction Steps

Prepared from 7,8-methylenedioxy-2-oxo-1,3-dihydro-2H-3-benzazepine and 2-(2-chloroethyl)-N-[3-(pyrid-4-yl)-propyl]-piperidine in dimethylsulphoxide and potassium tert.butoxide analogously to Example 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05175157
Source datasetuspto-grants-1992_12
ORD IDord-1991124153474b619c89c47a098932d2
Source noteuspto-grants-1992_12