HCID 19803905, compound → HCID 67917889, compound

HRID 1682063Notes

Reaction equation

HRID 1682063 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH:15]([CH2:18][N:19]3[C:25](=[O:26])[CH2:24][C:23]4[CH:27]=[C:28]5[O:33][CH2:32][O:31][C:29]5=[CH:30][C:22]=4[CH:21]=[CH:20]3)[CH2:14]2)=[CH:2]1.[H][H]>C(O)C.[Pd]>[OH2:26].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH:15]([CH2:18][N:19]3[C:25](=[O:26])[CH2:24][C:23]4[CH:27]=[C:28]5[O:33][CH2:32][O:31][C:29]5=[CH:30][C:22]=4[CH2:21][CH2:20]3)[CH2:14]2)=[CH:2]1

Participants

5

Reactant 2

HCID 19803905HCID 19803905, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67917889HCID 67917889, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Prepared from 3-[(N-(3-(indol-3-yl)-propyl)-pyrrolidin-3-yl)-methyl]-7,8-methylenedioxy-2-oxo-1,3-dihydro-2H-3-benzazepine with 20% palladium/charcoal at 5 bar hydrogen in ethanol at 80° C. analogously to Example 5.

Sources & evidence

ORD record
ord-8a949dcc0be6412db1fc47784c5eee73
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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