Noroxyhydrastinine → 2-[(N-(2-(4-Methoxy-phenyl)-ethyl)-hexahydro-azepin-3-yl)methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinolinehydrochloride

HRID 1682065Notes

Reaction equation

HRID 1682065 reaction equation
[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][NH:8][C:9]3=[O:14])=[CH:4][C:3]=2[O:2]1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][N:25]2[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]([CH2:32][Cl:33])[CH2:26]2)=[CH:19][CH:18]=1>>[ClH:33].[CH3:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][N:25]2[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]([CH2:32][N:8]3[CH2:7][CH2:6][C:5]4[C:10](=[CH:11][C:12]5[O:13][CH2:1][O:2][C:3]=5[CH:4]=4)[C:9]3=[O:14])[CH2:26]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 89047NoroxyhydrastinineHCID 19803941N-[2-(4-methoxy-phenyl)-ethyl]-3-chloromethylhexahydro-azepine

Product 1

HCID 198034982-[(N-(2-(4-Methoxy-phenyl)-ethyl)-hexahydro-azepin-3-yl)methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinolinehydrochloride

Procedure

Prepared from 6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydroisoquinoline and N-[2-(4-methoxy-phenyl)-ethyl]-3-chloromethylhexahydro-azepine analogously to Example 2.

Sources & evidence

ORD record
ord-361c7e96dacd45dea881a3873e4e9552
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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