6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one → HCID 19804151, compound

HRID 1682066Notes

Reaction equation

HRID 1682066 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9](=[O:15])[NH:8][CH2:7][CH2:6]2.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH2:26][CH2:27][N:28]2[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]([CH2:35][Cl:36])[CH2:29]2)[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]>>[ClH:36].[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH2:26][CH2:27][N:28]2[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]([CH2:35][N:8]3[CH2:7][CH2:6][C:5]4[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=4)[C:9]3=[O:15])[CH2:29]2)[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]

Participants

3

Reactant 2

HCID 6100976,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-oneHCID 19803860N-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-chloromethyl-hexahydro-azepine

Product 1

HCID 19804151HCID 19804151, compound

Procedure

Prepared from 6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline and N-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-chloromethyl-hexahydroazepine analogously to Example 2.

Sources & evidence

ORD record
ord-27808d2ac43a40a7a8a060a13b545fc5
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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