Noroxyhydrastinine → 2-[(N-(3-(3-Methyl-phenoxy)-propyl)-hexahydro-azepin-3-yl)methyl]-6,7-methylenedioxy-1-oxo-1,2.3,4-tetrahydro-isoquinolinehydrochloride

HRID 1682073Notes

Reaction equation

HRID 1682073 reaction equation
[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][NH:8][C:9]3=[O:14])=[CH:4][C:3]=2[O:2]1.[CH3:15][C:16]1[CH:17]=[C:18]([CH:32]=[CH:33][CH:34]=1)[O:19][CH2:20][CH2:21][CH2:22][N:23]1[CH2:29][CH2:28][CH2:27][CH2:26][CH:25]([CH2:30][Cl:31])[CH2:24]1>>[ClH:31].[CH3:15][C:16]1[CH:17]=[C:18]([CH:32]=[CH:33][CH:34]=1)[O:19][CH2:20][CH2:21][CH2:22][N:23]1[CH2:29][CH2:28][CH2:27][CH2:26][CH:25]([CH2:30][N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][C:12]4[O:13][CH2:1][O:2][C:3]=4[CH:4]=3)[C:9]2=[O:14])[CH2:24]1

Participants

3

Reactant 2

HCID 89047NoroxyhydrastinineHCID 19803932N-[3-(3-methyl-phenoxy)-propyl]-3-chloromethylhexahydro-azepine

Product 1

HCID 198035952-[(N-(3-(3-Methyl-phenoxy)-propyl)-hexahydro-azepin-3-yl)methyl]-6,7-methylenedioxy-1-oxo-1,2.3,4-tetrahydro-isoquinolinehydrochloride

Procedure

Prepared from 6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydroisoquinoline and N-[3-(3-methyl-phenoxy)-propyl]-3-chloromethylhexahydro-azepine analogously to Example 2.

Sources & evidence

ORD record
ord-cce05a2c48f94ec392ef12567c075a85
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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