HCID 19804667, compound → HCID 19804661, compound

HRID 1682102Notes

Reaction equation

HRID 1682102 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH3:10])[C:6](=[O:11])[N:5]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:4](=[O:18])[C:3]=1[N:19]=O.[H][H]>[Pd].C(O)C>[NH2:19][C:3]1[C:4](=[O:18])[N:5]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:6](=[O:11])[N:7]([CH2:8][CH2:9][CH3:10])[C:2]=1[NH2:1]

Participants

5

Reactant 2

HCID 19804667HCID 19804667, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 19804661HCID 19804661, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6-Amino-3-carboethoxymethyl-5-nitroso-1-propyluracil (2.84 g, 10 mmol) is slurried with 75 mL of absolute ethanol and 100 mg of 10% palladium-on-carbon. The mixture is hydrogenated at 25° C. and an initial pressure of 60 p.s.i. of hydrogen in a Parr apparatus. After uptake of hydrogen is completed the mixture is filtered and the filtrate concentrated to give the diaminouracil.

Workup

  1. customis hydrogenated at 25° C.
  2. filtrationis filtered
  3. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-82dcc81472a44cb08a201cf6b07130c9
Source dataset
uspto-grants-1992_12
Patent number
US05175290

Reaction notes

Loading…