反应详情

To a solution mixture comprising 50 ml of a 10% sodium hydroxide aqueous solution and 150 ml of methanol, 3.9 g of methyl 2-chloro-3-ethylthiomethyl-4-methanesulfonylbenzoate was added, and the mixture was stirred at room temperature for 30 minutes. Methanol was distilled off under reduced pressure, and a dilute hydrochloric acid was added to the residue for acid precipitation. The mixture was extracted with ethyl acetate, and the extract was dried. Then, the solvent was distilled off to obtain 3.5 g of the desired product. Melting point: 172°-174° C.

1. additionwas added
2. distillationMethanol was distilled off under reduced pressure
3. additiona dilute hydrochloric acid was added to the residue for acid precipitation
4. extractionThe mixture was extracted with ethyl acetate
5. customthe extract was dried
6. distillationThen, the solvent was distilled off