3-Isopropoxycarbonyl-4-methanesulfonyl-2-methylbenzoic acid → HCID 178428857, compound

HRID 1682159Notes

Reaction equation

HRID 1682159 reaction equation
[CH2:1]([N:3]1[C:7]([OH:8])=[CH:6][CH:5]=[N:4]1)C.OC1N(C)N=CC=1.CS(C1C=CC(C(O)=O)=C(C)C=1C(OC)=O)(=O)=O.[CH:34]([O:37][C:38]([C:40]1[C:41]([CH3:53])=[C:42]([CH:46]=[CH:47][C:48]=1[S:49]([CH3:52])(=[O:51])=[O:50])[C:43](O)=[O:44])=[O:39])([CH3:36])[CH3:35]>>[OH:8][C:7]1[N:3]([CH3:1])[N:4]=[C:5]([C:43](=[O:44])[C:42]2[CH:46]=[CH:47][C:48]([S:49]([CH3:52])(=[O:51])=[O:50])=[C:40]([C:38]([O:37][CH:34]([CH3:35])[CH3:36])=[O:39])[C:41]=2[CH3:53])[CH:6]=1

Participants

5

Reactant 4

HCID 151328763-Isopropoxycarbonyl-4-methanesulfonyl-2-methylbenzoic acidHCID 156236574-Methanesulfonyl-3-methoxycarbonyl-2-methylbenzoic acidHCID 178418331HCID 178418331, compoundHCID 178481816HCID 178481816, compound

Product 1

HCID 178428857HCID 178428857, compoundYield 45%

Procedure

The operation and treatment were conducted in the same manner as in Example 1 except that 1.12 g of 1-ethyl-5-hydroxypyrazole was changed to 0.98 g of 5-hydroxy-1-methylpyrazole, and 2.72 g of 4-methanesulfonyl-3-methoxycarbonyl-2-methylbenzoic acid was changed to 3.00 g of 3-isopropoxycarbonyl-4-methanesulfonyl-2-methylbenzoic acid, to obtain 1.71 g of the desired product. (Yield: 45%, melting point: 192°-194° C.)

Sources & evidence

ORD record
ord-228402091f744c3d8d8898fbedb6eb87
Source dataset
uspto-grants-1992_12
Patent number
US05175299

Reaction notes

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