Chloroform → HCID 19804744, compound

HRID 1682161Notes

Reaction equation

HRID 1682161 reaction equation
[OH:1][C:2]1[NH:6][N:5]=[C:4]([CH2:7][O:8][CH3:9])[CH:3]=1.[OH-].[K+].[CH3:12][S:13]([C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[C:18]([CH3:25])[C:17]=1[CH2:26][O:27][CH3:28])(=[O:15])=[O:14].[CH:29](Cl)(Cl)Cl>>[CH3:12][S:13]([C:16]1[CH:24]=[CH:23][C:19]([C:20]([O:1][C:2]2[N:6]([CH3:29])[N:5]=[C:4]([CH2:7][O:8][CH3:9])[CH:3]=2)=[O:21])=[C:18]([CH3:25])[C:17]=1[CH2:26][O:27][CH3:28])(=[O:15])=[O:14]

Participants

5

Reactant 4

HCID 6212ChloroformHCID 14797Potassium HydroxideHCID 19804754HCID 19804754, compoundHCID 178494559HCID 178494559, compound

Product 1

HCID 19804744HCID 19804744, compound

Procedure

1.9 g of 5-hydroxy-3-methoxymethylpyrazol was added to a mixture consisting of 8 ml of an aqueous solution containing 0.5 g of potassium hydroxide (85%) and 12 ml of chloroform, and then 4-methanesulfonyl-3-methoxymethyl-2-methylbenzoyl chloride was added thereto. The mixture was stirred for 3 hours at room temperature. Then, the reaction mixture was extracted with chloroform. The chloroform solution was washed with water and dried to obtain the desired product substantially quantitatively as an oily substance.

Workup

  1. extractionThen, the reaction mixture was extracted with chloroform
  2. washThe chloroform solution was washed with water
  3. customdried

Sources & evidence

ORD record
ord-d0b7ffee2a6940928e84821a1a70fa2d
Source dataset
uspto-grants-1992_12
Patent number
US05175299

Reaction notes

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