Pyridine → [[[5-[(2,5-Difluorophenyl)(4-fluorophenylsulfonyl)methyl]-4-methylpyridin-2-yl]carbonyl]amino]methyl Acetate

HRID 168217Notes

Reaction equation

HRID 168217 reaction equation
[CH3:32][C:33](=[O:34])[O:35][C:36](=[O:37])[CH3:38].[F:1][c:2]1[c:3]([CH:9]([c:10]2[c:11]([CH3:21])[cH:12][c:13]([C:16](=[O:17])[NH:18][CH2:19][OH:20])[n:14][cH:15]2)[S:22](=[O:23])(=[O:24])[c:25]2[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1.[cH:39]1[cH:40][cH:41][n:42][cH:43][cH:44]1>>[F:1][c:2]1[c:3]([CH:9]([c:10]2[c:11]([CH3:21])[cH:12][c:13]([C:16](=[O:17])[NH:18][CH2:19][O:20][C:33]([CH3:32])=[O:34])[n:14][cH:15]2)[S:22](=[O:23])(=[O:24])[c:25]2[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 119996905-[(2,5-difluorophenyl)[(4-fluorophenyl)sulfonyl]methyl]-N-(1-hydroxymethyl)-4-methylpyridine-2-carboxamide

Product 1

HCID 57736465[[[5-[(2,5-Difluorophenyl)(4-fluorophenylsulfonyl)methyl]-4-methylpyridin-2-yl]carbonyl]amino]methyl Acetate

Sources & evidence

ORD record
ord-a83562cc9173465fb5c05ff88d97f4d6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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