反应详情

In 500 ml of CHCl3 was dissolved 47.3 g (0.33 mole) of 6-chloro-3-pyridylmethanol followed by dropwise addition of 99.3 ml of thionyl chloride with stirring at room temperature. After completion of the dropwise addition, the mixture was further stirred for 1.5 hours and, then, allowed to stand overnight. The CHCl3 was distilled off under reduced pressure, whereby crystals and oil were obtained as a residue. The residue was diluted with ether, collected by filtration and dried to give 45.2 g of 6-chloro-3-pyridylmethyl chloride hydrochloride as white crystals.

1. additionAfter completion of the dropwise addition
2. stirringthe mixture was further stirred for 1.5 hours
3. distillationThe CHCl3 was distilled off under reduced pressure, whereby crystals
4. customoil were obtained as a residue
5. filtrationcollected by filtration
6. customdried