Methyl isothiocyanate → N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thiourea

Participants

Role	Name	HCID	Charge
Reactant	Methyl isothiocyanate	HCID 11167	—
Reactant	Ethyl[(pyridin-3-yl)methyl]amine	HCID 4716480	—
Solvent	Diethyl Ether	HCID 3283	—
Product	N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thiourea	HCID 22450434	100.3%

Reaction Conditions

Temperature	25 °C

Reaction Steps

In 50 ml of ethyl ether was dissolved 2.4 g of N-ethyl-N-(3-pyridylmethyl)amine followed by addition of 1.3 g of methyl isothiocyanate. The mixture was stirred at room temperature (25° C.) for 1 hour. The resulting precipitate was collected by filtration, washed with a small amount of ethyl ether and dried to give 3.7 g of N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thiourea as white prisms.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05175301
Source dataset	uspto-grants-1992_12
ORD ID	ord-fa15ae349e644721bf22c9c3ab55c84d
Source note	uspto-grants-1992_12