Hydrochloric Acid → HCID 360414, compound

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Reaction Steps

3-demethylthiocolchicine (100 mg) in pyridine (3 ml) is added with butylchloroformate (0.2 ml) under ice cooling. After 1 hour standing, the reaction mixture is adjusted to pH 5 by addition of 2N HCl and extracted with chloroform. After washing and drying as described in Example 5, 108 mg of 3-butoxycarbonyl-3demethylthiocolchicine is obtained as a yellow powder. mp 212°-215° C.; [α]D =-110.8° (c=0.3, CHCl3).

Provenance & Evidence