HCID 21667292, compound → HCID 86745085, compound

Participants

Reaction Steps

6.3 g of E-2-formylamino-3-methyl-5-diethylphosphono-3-pentenoic acid ethyl ester are heated for 30 hours at 100°-100° under nitrogen in 400 ml of 4.35 N hydrochloric acid. Working up as in Example 11 yields E-2-amino-3-methyl-5-phosphono-3-pentenoic acid in the form of a white powder, m.p. 168°, 1H-NMR (D2O): 1.50 (d, 3H, CH3); 2.4 (m, 2H, CH2); 4.30 (s, 1H, C(2)-H); 5.60 (m, 1H, C(4)-H).

Provenance & Evidence