Triethyl phosphite → HCID 86745095, compound

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Reaction Steps

3.7 g of E-2-formylamino-4-bromomethyl-3,6-heptadienoic acid methyl ester are dissolved in 37 ml of triethyl phosphite, and the mixture is heated at 75° for 8 hours. Excess triethyl phosphite is then distilled off under a high vacuum. Purification by column chromatography (silica gel, methanol/ethyl acetate 1:10) yields E-2-formylamino-4-diethylphosphonomethyl-3,6-heptadienoic acid methyl ester in the form of a colourless oil, H-NMR (CDCl3): 2.54 (d, 2H, P-CH:); 3.10 (m, 2H, C(5)-H); 5.10 (m, 2H, C(7)-H); 5.37 (d, 1H, C(2)-H); 5.74 (m, 1H, C(6)-H).

Provenance & Evidence